This Study Examined the Difference Between Prescription Vitamin D and OTC Vitamin D – Guess Which Was More Effective?
Many people write and ask, “My doctor prescribed a vitamin D called Drisdol, is that OK?”
Drisdol is the prescription form of vitamin D2, which is in fact different than what is produced by the body in response to sun exposure. Vitamin D2 is made by irradiating fungus and plant matter.
Some studies show D3 (produced by the skin) is more potent, meaning it is more effective at raising blood levels than D2, however, there are few studies comparing the efficacy of D2 vs. D3. In other words: which form has better health outcomes, better mortality rates, etc.?
Recently, a review and meta-analysis address this question. The meta-analysis study was led by Professor Dr. Goran Bjelakovic.
He analyzed 50 randomized controlled trials (RCTs) with a total of 94,000 participants that used some form of vitamin D and reported mortality rates as either primary or secondary outcomes. Within these RCTs, 32 of the studies used D3 (74,000 subjects) and 12 of them used D2 (18,000 subjects). He found there was a 6% relative risk reduction when supplementing with vitamin D3, as opposed to a 2% relative risk increase when supplementing with vitamin D2.
Amazingly, this study somehow slipped under the radar and neither the press nor I picked up this study in July. Luckily, Professor Dr. Harvey Murff of Vanderbilt University reviewed this study yesterday in the Annals of Internal Medicine recently, allowing the general public to examine the study once again.
You would think a paper that took a look at tens of thousands of subjects and analyzed the efficacy of prescription vitamin D (D2) and over-the-counter vitamin D (D3) would warrant a news story or two. To my knowledge, these papers are the first to paint such a clear picture about the efficacy between D3 and D2. While there may be explanations for D3’s superiority other than improved efficacy, for the time being, these papers send doctors a message: use D3, not D2.
Professor Harvey Murff, Vanderbilt University: email@example.com
Republished with permission from the Vitamin D Council.