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The #1 Deficiency Damaging Your Brain

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B12 Deficiency Brain ShrinkageDid you know that 1 in 8 Americans over the age of 65 has Alzheimer’s disease — and that nearly half of all individuals over the age of 80 suffer from this devastating condition?[1] Alzheimer’s is currently the sixth leading cause of death in the U.S. and is expected to cost our healthcare system roughly $200 billion dollars in 2012.[2] Did you know that correcting a simple nutrient deficiency that affects an estimated 1 in 2 older individuals could significantly reduce your risk of developing Alzheimer’s and dementia?

Deficiency: A Growing Epidemic

According to a report in the Harvard Health Newsletter, deficiency is the most common nutrient deficiency in the developing world and the U.S.[3] This is bad news since B12 is one of the building blocks your body uses to produce DNA. It also keeps your immune system functioning optimally, regulates mood and sleep cycles,[4] and is crucial to energy production, which is why it’s known as the “energy vitamin.”[5]

Signs and symptoms of a B12 deficiency include the following:

  • Low energy and weakness
  • Confusion or “fuzziness”
  • Persistent sleep problems
  • Digestive problems
  • Hearing and vision loss
  • Memory problems
  • Irritability and mood swings
  • Dizziness or lightheadedness
  • Weak immune function
  • Numbness and tingling in the hands and feet

I recommend vitamin B12 supplementation to my patients, and I am going to recommend it to you as well. Simply put, taking a high-quality B12 supplement can increase your energy and improve your overall state of well-being — and help preserve your brain function as you age.

Vitamin B12 Keeps Your Brain from Shrinking

The cognitive decline associated with aging has been clearly linked to a process in the body that involves a decrease in brain mass. That’s right, your brain actually shrinks as you get older! This reduction in brain mass is directly correlated with Alzheimer’s risk and the associated loss of memory and cognitive function seen in older individuals.[6]

A landmark study conducted in 2010 showed that supplementation with B12 in combination with B6 and folic acid slowed the accelerated rate of brain shrinkage and declining cognitive scores in older individuals with mild cognitive impairment.[7] While B6 and folic acid are readily available in the diet and easily absorbed, B12 is not, and severe B12 deficiency is thought to affect nearly 1 in 2 older adults,[8,9] making proper supplementation critical.

A more recent 2011 study published in the journal Neurology confirmed the importance of B12 in among older individuals.[10] It again showed that older individuals with higher levels of B12 in their blood had less shrinkage of the brain than counterparts with lower levels. Those with higher B12 blood levels and increased brain size also scored higher on memory and cognitive tests.

B12 protects your brain and nervous system by keeping nerves healthy and communicating in an optimal manner.[11,12] In addition, one of its most powerful protective properties for the brain is its ability to reduce blood levels of a dangerous metabolite called homocysteine. Homocysteine is a protein naturally formed in the body as a result of metabolism that is commonly correlated with many adverse health affects. Reductions in circulating homocysteine levels as a result of increased blood levels of B12 have been found to reduce the risk of developing Alzheimer’s disease. Being deficient in B12 puts your brain at serious risk by contributing to age-related brain shrinkage and elevated levels of homocysteine.[13]

Why You Should Start Taking a B12 Supplement Now

Many factors are contributing to the massive widespread rise in B12 deficiency. The most important is related to the fact that the body’s ability to absorb B12 decreases as we age. It has been clearly established that most people are deficient in B12 not because of a lack of consumption, but because they lack the ability to properly absorb it into the bloodstream.

Unlike almost all other vitamins, B12 must be separated from food by stomach acid in order to be absorbed. In addition, the body has to release a special binding protein called intrinsic factor to facilitate the passage of B12 into the blood stream. As we age, the cells in our stomach that make the stomach acid needed to cleave B12 from food and the intrinsic factor needed to absorb it significantly reduce in activity and potency. This leaves us with a severely compromised mechanism to extract and absorb B12 from our food. Therefore, a sublingual (under-the-tongue) B12 supplement that bypasses the digestive process becomes necessary in order to raise B12 blood levels.

Another major factor that contributes to B12 deficiency is prescription medication. Acid-blocking medications and the diabetes drug, metformin,[14] both deplete the body of B12. By the way, B12 supplements are extremely safe. B12 has no know drug interactions and has never shown any adverse or toxic effects in humans, even when given in large doses.

Take the Right B12 or Don’t Bother!

There are 2 main factors to consider when choosing a B12 supplement:

1. Sublingual Delivery: All oral B12 supplements should be delivered to the body by dissolving them under the tongue. The vast network of blood vessels under the tongue allows B12 to be absorbed directly into the blood stream and thus bypassing the issues related to stomach acid and intrinsic factor.

2. Activated Form: Most B12 supplements on store shelves and on the Internet are made with an inexpensive form of B12 called cyanocobalamin. The problem with this form of B12 is that your body cannot even utilize it! In order to have a beneficial effect on the health of your cells, it must first be converted into its active counterpart called methylcobalamin.

For these reasons, I ALWAYS suggest that anyone interested in supplementing with B12 use a supplement that contains 100% methylcobalamin delivered in a sublingual form. Human research has shown that supplementing with the active form of B12 is much more effective than using its inactive cyanocobalamin counterpart. The only reason why more companies don’t use active B12 in their supplements is to save money and increase the profit margins on products.

The B12 Supplement I Recommend

Stop Aging Now is a company that is leading the way in bringing to the market an affordable, high-potency sublingual methylcobalamin supplement of the highest quality. In addition to being the Medical Editor for Live in the Now, I am also a member of Stop Aging Now‘s Scientific Advisory Board. I worked with them to develop a cutting-edge B12 supplement called MAX-B12™ that I feel is the highest quality, most competitively priced supplement of its kind. Each pleasant tasting cherry-flavored lozenge delivers 1,000 mcg of activated B12, which is the minimum amount recommended by most experts. To ensure quality, all Stop Aging Now products are made in the U.S in an FDA inspected facility that meets cGMP (current Good Manufacturing Practices) and U.S. Pharmacopeia (USP) standards. Also, all of their products come with an industry leading 365-day unconditional money back guarantee.

If you want to start feeling more energized and mentally sharp AND ensure the health of your brain as you age, I recommend that you start taking Stop Aging Now‘s MAX-B12 methylcobalamin lozenges today.

Click here to get special pricing and free shipping on MAX-B12 from Stop Aging Now.

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  1. http://www.alzheimersprevention.org/alzheimers_disease.htm
  2. Alzheimer’s Association
  3. Harvard Health Letter – August 2005 Edition
  4. Mayer G, Kröger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996 Nov;15(5):456-64.
  5. Herbert V. Vitamin B12 in Present Knowledge in Nutrition. 17th ed. International Life Sciences Institute Press, 1996.
  6. American Health Assistance Foundation. 2000-2012 www.AHAF.com/alzheimers
  7. A. David Smith, Stephen M. Smith et al. Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLOS. Sept. 2010.
  8. Kimberly A Skarupski, Christine Tangney, et al. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr. 2000;71:514-22.
  9. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-77.
  10. Bowman, G. Neurology, published online Dec. 28, 2011.
  11. Taraneh Dormohammadi Toosi, Farhad Shahi, et al. Neuropathy caused by B12 deficiency in a patient with ileal tuberculosis: A case report. Eur J Pharm. 1993;241:1-6.
  12. Neurosci Lett. 2000;288:191-4.
  13. B. Hooshmand, MD, MSc, A. Solomon et al. Homocysteine and holotranscobalamin and the risk of Alzheimer disease. Neurology October 19, 2010vol. 75 no. 16 1408-1414.
  14. Jolien de Jager, Adriaan Kooy. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181.

Dr. Passero completed four years of post-graduate medical education at the National College of Naturopathic Medicine in Portland, Oregon after receiving a Bachelor’s Degree in Environmental Biology from the University of Colorado. Dr. Passero has trained with some of the nation’s leading doctors in the field of natural medicine. In his practice, Dr. Passero focuses on restoring harmony to both the body and mind using advanced protocols that incorporate herbal therapy, homeopathy, vitamin therapy and nutritional programs. Through education and guidance patients are able to unlock the natural healing power contained within each one of us. For more information, visit his website, Green Healing Wellness, or follow him on Facebook.



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Article updated on: March 29th, 2013

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3 Responses to “ The #1 Deficiency Damaging Your Brain ”

  1. natural products for health on October 20, 2012 at 7:29 PM

    Is B12 found occurring in nature, or can you only obtain it via commercial products?

  2. James Staudt on December 14, 2012 at 4:08 PM

    I give up! Who are we to believe? I just read an article on B12 and the relationship between it and prostate cancer in men. These medical people warned to not supplement with it. I wish you guys would all get together on this!!!

  3. joseph kurleto on February 17, 2013 at 5:11 PM

    Good article about the different way of using food to lower blood pressure.