Clue to Cognitive Decline Found in Blocking Brain Inflammation
For some time, scientists have been trying to unlock the secret to understanding how Alzheimer’s starts and progresses. Now, they may have found an important piece of the puzzle. In a new study, when brain inflammation was decreased by reducing the number of immune cells that cause it, some behavioral and memory problems associated with the disease were prevented. The discovery suggests the reduction in inflammation could halt the advancement of the illness.
Alzheimer’s is a devastating neurodegenerative disorder that affects 5.3 million Americans. It causes the deterioration of thinking, memory, behavior and quality of life. As the disease has no cure or effective treatment, the implications of the research are exciting.
Is Brain Inflammation Is the Driver of Alzheimer’s?
Studies have long indicated that the malfunction of the brain’s immune system plays a key role in Alzheimer’s. The new research to be published in the journal Brain sheds light on the role of Inflammation connected with this immune disruption. It adds to evidence that shows brain inflammation is the driver of the disease and not so much the result of the disease.
Scientists at the University of Southampton in the U.K. compared brain tissue samples of healthy people to those of Alzheimer’s patients. They found the brains of people with the disease had more microglia, a type of cell involved in immune responses like inflammation. In addition, they noted the molecules that regulated the microglia were more active in patients who had more severe cases of the illness.
Next, the research team examined the microglia in mice bred to develop a condition resembling Alzheimer’s. As the disorder progressed, the number of microglia increased in the brains of the animals. After giving the mice a chemical that prevented the rise in microglia, the loss of communication links between nerve cells that occurs in the disease was stopped. While the untreated mice continued to lose connections between their brain cells, the connections in the treated mice were maintained, resulting in less memory and behavioral problems.
The treatment enabled the mice to have the normal number of microglia required for a healthy brain immune system. A valuable aspect of the treatment is that it reduced the excessive number of microglia but didn’t reduce it lower than the optimal level.
While the treatment helped the inflammation, it had no effect on the buildup of amyloid plaque, another hallmark of Alzheimer’s. According to the researchers, this corroborates studies that indicate several physiological factors are responsible for the progression of the disease.
Curcumin Reduces the Brain Inflammation in Alzheimer’s
Despite the lack of improvement in amyloid plaque, the team felt the results were quite promising, and they intend to work on developing a drug that duplicates the action of the treatment. However, you don’t need to wait until the medication comes on the market to reduce the inflammation in your brain. In an interview with Live in the Now, Jacob Teitelbaum, M.D., author of Real Cause, Real Cure, said a natural, safe alternative to the proposed medication is already available.
“Fortunately, treatment effective against neural inflammation is already present, but it will be ignored by the health industry in favor of looking for patentable and profitable drugs. Curcumin, the spice that makes curry powder yellow, has been shown to be very effective against brain inflammation in Alzheimer’s and Parkinson’s. This is why the incidence of Alzheimer’s in India is 70 percent lower than in America.”
Mary West is a natural health enthusiast, as she believes this area can profoundly enhance wellness. She is the creator of a natural healing website where she focuses on solutions to health problems that work without side effects. You can visit her site and learn more at http://www.alternativemedicinetruth.com. Ms. West is also the author of Fight Cancer Through Powerful Natural Strategies.